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Making Contact

banks. When applied as a biological by McDonald et al, supported his from the eye, providing symptomatic
corneal bandage, it has powerful findings. Her team found 88 per cent relief for weeks to months at a time,
anti-inflammatory, anti-angiogenic, of 84 patients showed improved ocular depending on the severity of the DED,
immunomodulatory and anti-scarring surface as well as a remarkable with reapplication for recurrences as
properties. It facilitates apoptosis of reduction in the overall DEWS score. needed. 5
the neutrophils/macrophages and The restoration of corneal health also
4
inhibits the action of lymphocytes to lasted at least three months on average. Adding CAM or DAM to your
protect, repair and restore the ocular PROKERA is like a large contact lens. armamentarium is not only wise; it
surface. It is also rich in nerve growth It is made up of either a single or also provides support and hope to
factors (NGF), which helps with double layer of AM, with or without desperate patients with moderate-to-
corneal nerve regeneration and a clear 6mm aperture, that is spread advanced DED. These patients would
epithelial healing. 2 across a regular or thin polymethyl have seen many doctors and spent
In a prospective randomized clinical methacrylate ring. It is inserted with thousands of dollars on treating
trial by John et al, he reported blunt forceps, one eye at a time, their DED. They would have had low
significant corneal nerve restoration in because of its non-transparency productivity at work or be absent
17 subjects wearing the CAM for 3-5 and the expected accumulation of from it due to their discomfort and
days, as compared to the control group inflammatory debris during the vision disturbance. This all has a huge
using conventional maximum DED healing period. To maintain the tear impact on the economy and their
treatment. He found increased corneal film stability within the ecosystem
nerve density/sensitivity as well as and prevent the conformer ring from everyday lives. This is an opportunity
improvement in corneal topography, frictionally rubbing over the ocular to help reduce that economic burden.
dry eye signs (corneal staining, TBUT) surface, medical tape may be used Moreover, these patients will be your
and symptomology (reduced pain, to partially close the upper lid. Once best advocates after you help resolve
SPEED, and DEWS scores). Another the AM graft melts away naturally in their dry eye symptoms and recover
3
retrospective larger-scaled study done five to seven days, the ring is removed their corneal health. l
E
1 “TFOS International Dry Eye Workshop (DEWS II) Report”, The Ocular Surface, vol. 15 (3): A1-A10, 269-650, July 2017
2 Touhami A, Grueterich M, Tseng SC, “The role of NGF signaling in human limbal epithelium expanded by amniotic membrane culture”, Invest Ophthalmol Vis Sci, vol. 43 (3): 987-94, April 2002
3 John T, Tighe S, Sheha H, Hamrah P et al, “Corneal nerve regeneration after self-retained amniotic membrane in dry eye disease”, J Ophthalmol, Vol. 2017: 6404918, 10 pages
4 McDonald MB, Sheha H, Tighe S et al, “Treatment outcomes in the DRy eye amniotic membrane (DREAM) study”, Clin Ophthalmol, vol. 12: 677-681, April 2018
5 Biotissue company website: https://www.biotissue.com/prokera/ (accessed April 14, 2021)

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